Buffalo Bills Pro Bowl running back LeSean McCoy Youth Tremaine Edmunds Jersey , ’s loss to the Indianapolis Colts, took another step forward in his quest to play vs. the New England Patriots Monday night.While McCoy remains in the league’s concussion protocol, he was able to return to practice on a limited basis Thursday, and the hope remains that Buffalo’s most dynamic offensive play maker will return to action when Buffalo hosts its first Monday Night Football game in nearly a decade. The league’s concussion protocol is a complicated, five-step process, and McCoy has already passed through the first four steps: rest and recovery, light aerobic exercise, and continued aerobic exercise/strength training are the first three hurdles a player must climb before being cleared to play. Step four is resuming football specific activities, in this case being limited Thursday in practice. So far, McCoy appears to have endured all of these activities without displaying any of the concussion-like symptoms that plagued him after the hit in the Colts game. The last hurdle for McCoy: full football activity/medical clearance to play. These are all great signs for McCoy, who though he hasn’t scored a touchdown yet this year Authentic Matt Milano Jersey , is still Buffalo’s best offensive play maker. McCoy has a history of success playing for the Bills vs. the Patriots. In each of Buffalo’s last five showdowns with New England, McCoy has racked up 100-plus total yards from scrimmage, including 147 yards from scrimmage in a Week 16 loss at Foxboro, and 123 total yards from scrimmage the last time these teams met on Monday Night Football: a 20-13 loss Nov. 23, 2015. In other injury news from Thursday, five Bills were held out of practice: LB Lorenzo Alexander (rest day), quarterback Josh Allen (elbow), RB Taiwan Jones (neck), DE Trent Murphy (knee), and DT Kyle Williams (rest day). The Bills (2-5) look to snap a two-game losing streak when the rival Patriots (5-2) come to New Era Field for an 8:15 primetime game Monday night. This will be Buffalo’s first Monday Night Football game since a 31-25 road loss to the Seattle Seahawks on Nov. 7, 2016 Micah Hyde Jersey , and the first home MNF game since a 29-27 loss to the Cleveland Browns on Nov. 17, 2008. Monday’s game will occur on the 45th anniversary of the first-ever Monday Night Football game in franchise history, a 23-14 win at Rich Stadium over the Kansas City Chiefs on Oct. 29, 1973. In a slight show of gamesmanship, the Buffalo Bills listed all three of their most severely injured players as questionable on Friday ahead of the weekend’s showdown with the Tennessee Titans. Micah Hyde, Rafael Bush, and Charles Clay all technically have a chance to play on Sunday.To be realistic, though, it wouldn’t be a shock to see both Hyde and Bush out of the picture this weekend. Following his original injury diagnosis, Hyde (groin) was labelled “week-to-week” by head coach Sean McDermott, and he didn’t practice at all this week. Bush (shoulder) also failed to practice from Wednesday through Friday Bills Rafael Bush Jersey , and though he’d be needed with Hyde out, his availability may stretch out one more week.Charles Clay (ankle) followed a similar trajectory to last week, just with a different injury. After missing practice on Thursday, he was a full participant on Friday, and it wouldn’t be surprising to see him on the field against the Titans.Shaq Lawson and Marcus Murphy were both listed sans injury designation this week, which means if either one is held out of the game on Sunday, it wouldn’t be due to health.The Titans will be without starting safety Kenny Vaccaro or linebacker Wesley Woodyard, but most of their roster is fully intact.